Andrographis paniculata
·
Acanthaceae
·
Southern & Southeast Asia

Chiretta

Green chiretta, King of Bitters

Useful parts

Leaves, Roots, Stems

Key actions

Immunostimulant, Antibacterial, Antiviral, Anti-inflammatory, Anticancer (preclinical), Antispasmodic, Hypotensive

Active compounds

Terpenoid lactones (Andrographolide)

This Site is for Educational Use Only: The information on this page is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. I am not a licensed medical professional. Always consult a qualified healthcare provider before using any medicinal plants, especially if you are pregnant, nursing, taking medications, or have a medical condition.

Possible Proposed Uses

  • Colds
  • Flu
  • Fever
  • Upper respiratory infections
  • Liver disorders
  • Rheumatoid arthritis
  • Ulcerative colitis

Mechanism of Action

  • Modulates cytokines
  • Prevents influenza virus binding
  • Inhibits calcium channels (smooth muscle relaxation)
  • Antioxidant activity

Possible Side Effects

  • Possibly unsafe in pregnancy
  • May worsen autoimmune diseases

Possible Drug Interactions

  • Antihypertensives
  • Immunosuppressants
  • Anticoagulants
  • Antiplatelets
  • Avoid in autoimmune disease

Abigail's notes

Chiretta is native to India and has been highly valued in both Ayurvedic and Chinese medicine for a very long time. It's one of those plants that hasn't made much of a dent in Western herbal medicine yet but absolutely deserves more attention than it gets here.

The whole plant is used, which is always a fun detail. And it is intensely bitter, which as we've established throughout this database means it's doing useful things for your digestive and liver activity before it even gets to its other jobs.

Those other jobs are pretty impressive. Chiretta battles infection, treats dysentery, fever, malaria, and worms, and functions as both an anti-inflammatory and an immune stimulant. For a plant that isn't exactly a household name in the West, that's a serious resume.

The most exciting current development is that chiretta is actively being investigated for its potential role in cancer treatment. Which puts it in that category of plants where traditional medicine has been pointing at something important for centuries and modern research is finally catching up to ask why. Rooting for this one to get the studies it deserves.

Safety note: Excessive dosage can cause stomach upset, so stick to recommended amounts. Avoid during pregnancy and breastfeeding. Given that research is still developing on some of its more significant proposed uses, approaching this one with appropriate curiosity and practitioner guidance is the smart move.

Last updated on:
May 20, 2026

Deeper research options for you (because I would never ask you to just take my word for it)

Andrographis paniculata https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts/andrographis-paniculata

Physiological Activities of the King of Bitters (Andrographis paniculata): A Review https://pmc.ncbi.nlm.nih.gov/articles/PMC10501175/

Harnessing the medicinal properties of Andrographis paniculata for diseases and beyond: a review of its phytochemistry and pharmacology https://pmc.ncbi.nlm.nih.gov/articles/PMC4032030/

Herbal Remedies by Andrew Chevallier

Disclaimer: The content on this website is provided for informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. No provider-patient relationship is created by use of this site. The author makes no representations regarding the accuracy or completeness of the information and assumes no liability for any adverse effects resulting from the use of plants or remedies described herein.

Know your sources.
Magnifying glass over a web browser window, symbolizing source verification or fact checking.

Check the source, not just the headline

Who wrote it? What are their credentials? Who published it and why? A wellness blog and a peer-reviewed journal are not the same thing, even when they say the same words. Always click through to the original source.

Illustration of a colorful calendar grid with five rows and seven columns on a black background.

Check the date

Science updates over time. A 2003 study on a supplement may have been contradicted twelve times since. Always look for the publication date and whether newer research exists. "Studies show" means nothing without a timestamp.

A relaxed cartoon bear lying down holding a fan of dollar bills in one hand.

Follow the money

Who funded the study? A supplement company funding research on their own supplement is a conflict of interest. It's not automaticly a disqualification, but worth noting. Look for the "funding" or "disclosures" section of any study you read.

Open book with a red bookmark, a DNA helix above it, and a yellow liquid-filled laboratory flask.

Understand study types

Not all research is equal. A randomized controlled trial carries more weight than a case study or an animal study. "A study found..." could mean ten people in a lab or a decade-long population study. The difference matters enormously.

Document labeled Reference with a magnifying glass icon and lines of text.

Cross-reference everything

If only one source is saying something, be skeptical. If ten independent sources across different institutions, different countries, different decades are saying the same thing, you're getting warmer. Consensus is earned, not declared. Studies should be peer reviewed.

Hands holding a medical document with a pink cross and a shield with a checkmark symbolizing health protection.

Use the NIH and examine.com

The National Institutes of Health database (PubMed) is free and searchable. Examine.com aggregates supplement research without selling anything. Both are significantly more reliable than any wellness influencer, including me.