Passiflora spp.
·
Passifloraceae
·
Mexico, Central & South America

Passionflower

Maypop, Apricot Vine, Granadilla, Lilikoi

Useful parts

Leaves, Flowers, Stems, Roots, Fruit pulp/juice

Key actions

Sedative, Anxiolytic, Antispasmodic, CNS calming

Active compounds

Alkaloids (harman, harmaline), Flavonoids, Glycosides, Cyanogenic glycosides (in some species)

This Site is for Educational Use Only: The information on this page is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. I am not a licensed medical professional. Always consult a qualified healthcare provider before using any medicinal plants, especially if you are pregnant, nursing, taking medications, or have a medical condition.

Possible Proposed Uses

  • Insomnia
  • Anxiety
  • Hysteria
  • Epilepsy
  • ADHD
  • Nerve pain
  • Menstrual symptoms

Mechanism of Action

  • May inhibit reuptake of serotonin and dopamine
  • Activates GABA receptors
  • Antioxidant and anti-inflammatory effects

Possible Side Effects

  • Dizziness
  • Confusion
  • Uterine contraction (unsafe in pregnancy)

Possible Drug Interactions

  • Avoid with sedatives
  • Avoid with CNS depressants
  • Avoid during pregnancy

Abigail's notes

Passionflower was named by colonists who thought it looked like the crucifixion, which is a very colonist thing to do with a plant that indigenous people had been using and presumably naming long before anyone showed up to rename it. I do genuinely wonder what it was called before that. Something worth looking into.

Indigenous use of this plant is rich and varied. In Peru it was used to treat boils, wounds, earache, and liver conditions. The Aztecs used it for snake bites and fevers. The Cherokee used it as food. The Houma made it into tea and eventually shared that with the colonists, who then named it after the crucifixion. As one does.

It is admittedly a slightly strange looking flower, all tendrils and alien geometry, but what it does is anything but strange. Passionflower is a calming relaxant and sleep aid with a solid reputation for exactly those applications. It's antispasmodic, making it useful for spasmodic pain, and works gently enough that it's one of the more approachable options for people newer to herbal remedies for anxiety or sleep issues.

The calming properties connect directly to that long history of use across so many different cultures. When that many independent traditions land on the same application, it's worth paying attention.

Safety note: Allergic reactions are rare but possible. Avoid during pregnancy. If you're on sedatives or anti-anxiety medications, check with your provider before adding passionflower given its calming effects.

Last updated on:
May 20, 2026

Deeper research options for you (because I would never ask you to just take my word for it)

Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology https://pmc.ncbi.nlm.nih.gov/articles/PMC7251050/

Passionflower https://www.nccih.nih.gov/health/passionflower

Pharmacological studies of Passiflora sp. and their bioactive compounds https://academicjournals.org/article/article1380125484_Ingale%20and%20Hivrale.pdf

Herbal Medicinal Products from Passiflora for Anxiety: An Unexploited Potential https://pmc.ncbi.nlm.nih.gov/articles/PMC7387951/

Sacred Herbs by Opal Streisand

Herbal Remedies by Andrew Chevallier

Disclaimer: The content on this website is provided for informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. No provider-patient relationship is created by use of this site. The author makes no representations regarding the accuracy or completeness of the information and assumes no liability for any adverse effects resulting from the use of plants or remedies described herein.

Know your sources.
Magnifying glass over a web browser window, symbolizing source verification or fact checking.

Check the source, not just the headline

Who wrote it? What are their credentials? Who published it and why? A wellness blog and a peer-reviewed journal are not the same thing, even when they say the same words. Always click through to the original source.

Illustration of a colorful calendar grid with five rows and seven columns on a black background.

Check the date

Science updates over time. A 2003 study on a supplement may have been contradicted twelve times since. Always look for the publication date and whether newer research exists. "Studies show" means nothing without a timestamp.

A relaxed cartoon bear lying down holding a fan of dollar bills in one hand.

Follow the money

Who funded the study? A supplement company funding research on their own supplement is a conflict of interest. It's not automaticly a disqualification, but worth noting. Look for the "funding" or "disclosures" section of any study you read.

Open book with a red bookmark, a DNA helix above it, and a yellow liquid-filled laboratory flask.

Understand study types

Not all research is equal. A randomized controlled trial carries more weight than a case study or an animal study. "A study found..." could mean ten people in a lab or a decade-long population study. The difference matters enormously.

Document labeled Reference with a magnifying glass icon and lines of text.

Cross-reference everything

If only one source is saying something, be skeptical. If ten independent sources across different institutions, different countries, different decades are saying the same thing, you're getting warmer. Consensus is earned, not declared. Studies should be peer reviewed.

Hands holding a medical document with a pink cross and a shield with a checkmark symbolizing health protection.

Use the NIH and examine.com

The National Institutes of Health database (PubMed) is free and searchable. Examine.com aggregates supplement research without selling anything. Both are significantly more reliable than any wellness influencer, including me.